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SPOREA well-documented dead end is worth more than a glib unification.

Interdisciplinary scientific hypotheses no one has proposed yet.

Latest brief·SPR-2026-3A8D
Gene expression and cancer classification×Geochemistry and Geologic Mapping

Cancer: could the background noise of DNA microarrays conceal the true signals?

Imagine that you must deduce the menu of a dinner from the composition of each guest’s plate. But each plate is filled to the brim: if you add more mashed potato, there is necessarily less meat, even if the cook served the same amount of meat to everyone. This is the problem of DNA microarrays: the total measurement is fixed, so an increase in one gene mechanically lowers the others. The proposed transformation amounts to weighing each ingredient separately before placing it on the plate, in order to recover the true proportions.

NoveltyScore self-assigned by the LLM. It is a heuristic, not an objective measurement — see Methodology.
0.85
novel
Panel consensus
6.4/10
published
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How SPORE works

Collision, validation, publication

A system that randomly collides distant scientific domains, queries the actual literature, and publishes only what survives a panel of five specialised reviewers.

01
🎲

Collision

Two distant domains are drawn at random. A filter rejects trivial pairs.

02
🧪

Validation

Five AI reviewers — methodologist, domain expert, devil's advocate, industry reviewer, funding strategist — challenge the hypothesis.

03
📄

Publication

A brief grounded on Semantic Scholar, with a three-phase protocol and an actionable quick-start.

4,425
Collisions explored
41
Briefs published
0.79
Average noveltyScore self-assigned by the LLM. It is a heuristic, not an objective measurement — see Methodology.
100%
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